|
KMID : 1059519960400120711
|
|
Journal of the Korean Chemical Society
1996 Volume.40 No. 12 p.711 ~ p.718
|
|
|
Structure-Activity Relationship. A Theoretical Study of 1-phenylpyrrolidine-2,5-diones on the Antifungal Activities
|
|
Park Seong-Sik
Choi Sang-Tae
Kim Sang-Yun
Yoh Soo-Dong
|
|
|
Abstract
|
|
|
|
The relationship between chemical structure and antifungal activity of benzene ring substituents of 1-phenylpyrrolidine-2,5-diones is studied by testing of model compounds and use of conformational data. The analysis revealed a number of structural features as essential for the antifungal effect: (1) the presence of an intact-NCO group and benzene moiety; (2) the distance between para substituents and the N atom within the 5.318∼5.320 Å range; (3) the distance between substituent X3 and X5 in the interval 5.437∼6.072 Å for the active analogues. And other parameters were discussed.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|